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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Two new flavonoids from Origanum vulgare
Usama W Hawas1, S K El-Desoky, S A Kawashty
1Phytochemistry and Plant Systematics Department, National Research Centre, Cairo, Egypt.
Natural Product Research
|November 22, 2008
Summary
Researchers identified two novel flavonoids, luteolin 7-O-alpha-L-rhamnoside-4'-O-beta-D-glucoside and quercetin 3-O-beta-D-glucoside-4'-O-alpha-L-rhamnoside, in Origanum vulgare L. These compounds were isolated from a methanolic extract using advanced analytical techniques.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Origanum vulgare L. (oregano) is a widely used medicinal herb.
- Previous studies have identified numerous compounds in oregano, including various flavonoids.
Purpose of the Study:
- To isolate and characterize novel flavonoid compounds from the methanolic extract of Origanum vulgare L.
- To contribute to the understanding of the phytochemical profile of Origanum vulgare L.
Main Methods:
- Methanolic extraction of Origanum vulgare L. plant material.
- Isolation of compounds using conventional chromatographic techniques.
- Structure elucidation using Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectral analysis.
Main Results:
- Two new flavonoid glycosides were isolated and identified: luteolin 7-O-alpha-L-rhamnoside-4 -O-beta-D-glucoside and quercetin 3-O-beta-D-glucoside-4 -O-alpha-L-rhamnoside.
- Several known flavonoids, including apigenin and luteolin derivatives, were also identified.
- The structures of the new compounds were confirmed through comprehensive spectroscopic analysis.
Conclusions:
- The phytochemical investigation of Origanum vulgare L. led to the discovery of two previously undescribed flavonoid structures.
- This study expands the knowledge of the chemical constituents present in Origanum vulgare L., particularly its flavonoid diversity.
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