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Updated: Jun 27, 2026

Isolation of Lymphocytes from Mouse Genital Tract Mucosa
Published on: September 3, 2012
Functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal
E V Nagurskaya1, L G Zaitseva, N V Kobets
1N. F. Gamaleya Institute of Epidemiology, Russian Academy of Medical Sciences, Moscow.
Abstract:
In the early period after intravaginal infection with herpes simplex virus type 2 (2 h), macrophages from sensitive DBA/2 mice were characterized by higher capacity to engulf the antigen, decreased function of the lysosomal apparatus, lower activity of cathepsin D, and reduced oxygen metabolism compared to cells from resistant BALB/c mice. Mucosal vaccination with herpes vaccine and hyaluronic acid promoted the increase in functional activity of macrophages and improved survival of sensitive mice (by 60%).

