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Related Experiment Video

Updated: Jun 27, 2026

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

Published on: April 9, 2018

Leukocyte adhesion defect.

Hamid Nawaz Tipu¹, Awais Tahir, Tahir Aziz Ahmed

¹Armed Forces Institute of Pathology, Rawalpindi.

JPMA. the Journal of the Pakistan Medical Association

|November 26, 2008

Summary

This summary is machine-generated.

Leukocyte adhesion defect (LAD) is a rare immunodeficiency where phagocytes cannot reach infection sites due to absent surface integrins. Diagnosis involves flow cytometry confirming absent integrins on neutrophils.

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Area of Science:

Immunology
Genetics
Hematology

Background:

Leukocyte adhesion defect (LAD) is a rare, autosomal recessive primary immunodeficiency.
It affects phagocyte function, impairing their aggregation at infection sites.
This defect stems from the absence of crucial surface integrins.

Observation:

A 7-month-old boy presented with recurrent infections.
He exhibited marked leukocytosis and delayed umbilical cord separation.
These symptoms are characteristic of LAD.

Findings:

Flowcytometric analysis was used for diagnosis.
The analysis demonstrated the absence of integrins on the patient's neutrophils.
This confirmed the diagnosis of LAD.

Implications:

Accurate diagnosis of LAD is critical for patient management.
Flow cytometry is a key diagnostic tool for LAD.
Understanding LAD pathogenesis aids in developing potential therapeutic strategies.