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Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

Updated: Jun 27, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
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Atherothrombosis: environmental links.

E Stoupel1

  • 1Division of Cardiology, Rabin Medical Center, Petah Tiqwa, Israel. stoupel@inter.net.il

Journal of Basic and Clinical Physiology and Pharmacology
|November 26, 2008
PubMed
Summary

Environmental factors like solar activity, geomagnetic fields, and cosmic rays significantly influence cardiovascular health. Geomagnetic activity is linked to blood coagulation and inflammation, while cosmic rays correlate with acute myocardial infarction and stroke events.

Area of Science:

  • Cardiovascular Medicine
  • Environmental Science
  • Space Physics

Background:

  • Cosmo-terrestrial influences on human homeostasis have been studied for decades.
  • Atherothrombosis is a primary mechanism in vascular catastrophes.
  • This study focuses on environmental physical activity and its links to cardiovascular events.

Purpose of the Study:

  • To summarize studies on environmental physical activity and cardiovascular medicine.
  • To investigate the links between solar activity (SA), geomagnetic activity (GMA), and cosmic ray activity (CRA) with atherothrombosis.
  • To analyze the relationship between these environmental factors and major vascular events.

Main Methods:

  • Comparative analysis of clinical events (acute myocardial infarction, sudden cardiac death, stroke) and laboratory data (coagulation, inflammation).

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  • Correlation of clinical and laboratory data with parameters of SA, GMA, and CRA, including high-energy space proton flux.
  • Data sourced from studies in Lithuania and Israel, with physical data from US and Russian space institutions.

    • Main Results:

    • Significant associations found between GMA levels and blood coagulation parameters (platelets, fibrinogen, INR), inflammation markers (CRP), anti-phospholipid syndrome, and deaths from ischemic stroke, sudden cardiac death, and myocardial infarction.
    • Monthly occurrence of acute myocardial infarction correlated with CRA.
    • Monthly deaths from ischemic stroke correlated with CRA; both events linked to atherothrombosis.

    Conclusions:

    • Atherothrombosis components (coagulation, inflammation, plaque disruption) are linked to environmental physical activity.
    • Cosmic ray activity (CRA) is predominant in plaque disruption, cellular damage, and electrical instability.
    • Geomagnetic activity (GMA) is implicated in the activation of coagulation and inflammation.