Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Actin Filament Depolymerization01:19

Actin Filament Depolymerization

Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
In F-actin, the ADF/cofilin proteins...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Formation of Higher-order Actin Filaments01:11

Formation of Higher-order Actin Filaments

The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin networks...
Types of Intermediate Filaments01:31

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y-Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon.

Molecular plant pathology·2026
Same author

Whole β-glucan particles modulate BCG-induced macrophage and CD4<sup>+</sup> T-cell responses via the Dectin-1-JAK1/STAT1 pathway.

Communications biology·2026
Same author

Mycobacterium tuberculosis MEM39 (Rv1977) hijacks host aldolase A (ALDOA) to subvert immunometabolism to facilitate bacterial intracellular survival.

Cellular & molecular immunology·2026
Same author

Deficiency of the Mycobacterial Lipoarabinomannan Biosynthesis Glycosyltransferase MptC Enhances Antibacterial Immune Response and Rifapicin Antibiotic Susceptibility.

Antibiotics (Basel, Switzerland)·2026
Same author

Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosis.

Bioorganic chemistry·2026
Same author

Author Correction: EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses.

Nature communications·2025

Related Experiment Video

Updated: Jun 27, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Ficolins: structure, function and associated diseases.

Xiao-Lian Zhang1, Mohammed A M Ali

  • 1The State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune-related Diseases, Wuhan University School of Medicine, Wuhan, 430071, P.R. China. ZhangXL65@whu.edu.cn

Advances in Experimental Medicine and Biology
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Ficolins are innate immune molecules that recognize pathogens and damaged cells. Their dysfunction is linked to various diseases, offering potential therapeutic targets for immune system modulation.

More Related Videos

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
08:57

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

Imaging Intranuclear Actin Rods in Live Heat Stressed Drosophila Embryos
07:57

Imaging Intranuclear Actin Rods in Live Heat Stressed Drosophila Embryos

Published on: May 15, 2020

Related Experiment Videos

Last Updated: Jun 27, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
08:57

Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

Imaging Intranuclear Actin Rods in Live Heat Stressed Drosophila Embryos
07:57

Imaging Intranuclear Actin Rods in Live Heat Stressed Drosophila Embryos

Published on: May 15, 2020

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathogenesis

Background:

  • Ficolins are humoral pattern recognition molecules crucial for innate immunity.
  • They identify carbohydrate structures on pathogens and host cells.
  • Human ficolins include L-ficolin, H-ficolin, and M-ficolin, structurally similar to collectins.

Purpose of the Study:

  • To review the structures and functions of ficolins.
  • To summarize the clinical implications and roles of ficolins in human diseases.
  • To highlight ficolins as potential therapeutic targets.

Main Methods:

  • Literature review of ficolin research.
  • Analysis of ficolin structure and function.
  • Summary of clinical studies on ficolin involvement in diseases.

Main Results:

  • Ficolins initiate complement activation via the lectin pathway and mediate opsonophagocytosis.
  • Ficolin dysfunction is associated with infectious, inflammatory, and autoimmune diseases.
  • Specific diseases linked to ficolins include recurrent respiratory infections, lupus erythematosus, and IgA nephropathy.

Conclusions:

  • Ficolins play a vital role in innate immunity and disease pathogenesis.
  • Understanding ficolin functions provides insights into disease mechanisms.
  • Ficolins represent promising targets for novel immunotherapeutic strategies.