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Updated: Jun 27, 2026
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High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
Published on: January 23, 2018
Insulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome
Sidhartha Das1, Bijay Misra, Laxmidhar Roul
1Department of Medicine, S.C.B. Medical College and Hospital, Cuttack, India. sidhartha_cuttack@yahoo.co.in
Metabolic Syndrome and Related Disorders
|November 26, 2008
Summary
Insulin resistance (IR) and beta cell function are key indicators in critically ill patients with multi-organ dysfunction syndrome (MODS). Impaired beta cell function correlates with higher mortality, suggesting overexhaustion contributes to sepsis progression.
Area of Science:
- Endocrinology
- Critical Care Medicine
- Pathophysiology
Background:
- Insulin resistance (IR) plays a significant role in the development of sepsis.
- Critically ill patients often experience multi-organ dysfunction syndrome (MODS).
Purpose of the Study:
- To assess insulin resistance and beta cell function in critically ill patients with MODS.
- To determine the correlation between IR, beta cell function, and patient mortality.
Main Methods:
- Utilized the homeostasis model assessment (HOMA-A and HOMA-B) to evaluate IR and beta cell function.
- Studied 80 consecutive critically ill patients diagnosed with MODS using modified APACHE II criteria.
- Monitored 60 patients up to day 7, recording mortality and recovery data.
Main Results:
- Initial high insulin and IR levels decreased significantly in recovering patients (p < 0.05).
- Patients who died exhibited high initial insulin/IR but significantly lower beta cell function compared to survivors (p < 0.05).
- Beta cell overexhaustion was observed, particularly in patients with fewer than 4 organ failures.
Conclusions:
- Beta cell failure is evident early in moribund patients with multiple organ failures or those who died.
- Insulin resistance and beta cell function serve as reliable indicators of critical illness severity.
- These metabolic parameters correlate with mortality in patients with MODS.
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