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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 27, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Ebp1 expression in benign and malignant prostate.

Philippe O Gannon1, Ismaël Hervé Koumakpayi1, Cécile Le Page1

  • 1Centre de recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal. 1560 rue Sherbrooke East, Montreal, Quebec, Canada.

Cancer Cell International
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

ErbB3-binding protein 1 (Ebp1) expression increases with prostate cancer progression. While Ebp1 alone doesn't predict recurrence, its combination with Cyclin D1 is an independent predictor of PSA relapse in prostate cancer (PCa).

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Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • ErbB3-binding protein 1 (Ebp1) is a proliferation-regulated protein found in various cells.
  • The role of Ebp1 in prostate cancer (PCa) progression in vivo remains largely unknown.
  • EGFR family members, including ErbB3, are implicated in cancer development.

Purpose of the Study:

  • To investigate Ebp1 expression in normal, cancerous, and hormone-refractory prostate tissues.
  • To correlate Ebp1 levels with Androgen Receptor (AR), Cyclin D1, ErbB3, and Ki67.
  • To assess the association between Ebp1 expression and biochemical recurrence (BCR) post-prostatectomy.

Main Methods:

  • Immunohistochemistry was used to evaluate Ebp1, AR, Cyclin D1, ErbB3, and Ki67 expression.
  • Analysis included normal, adjacent non-cancerous, hormone-sensitive, and hormone-refractory PCa tissues.
  • Multivariate COX regression analysis correlated Ebp1 with PCa progression and clinical parameters.

Main Results:

  • Ebp1 expression significantly increased from normal to hormone-sensitive and hormone-refractory PCa.
  • Strong correlations were observed between Ebp1 and nuclear AR, Cyclin D1, and ErbB3 expression.
  • A combination of Ebp1-positive and Cyclin D1-negative status independently predicted PSA relapse (HR 4.79).

Conclusions:

  • Ebp1 expression correlates with prostate cancer progression in vivo.
  • Ebp1 alone did not significantly predict PSA relapse, but its combination with Cyclin D1 did.
  • This study is the first to demonstrate Ebp1's association with PCa progression in vivo.