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Updated: Jun 27, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors
Geraldine C Diaz1, Joan Prowda, Irene J Lo
1Department of Anesthesiology, University of Arizona, Tucson, AZ 85724, USA.
Abstract:
Transplantation-mediated alloimmune thrombocytopenia (TMAT) is donor-derived thrombocytopenia following solid-organ transplantation. To date, no clear consensus on the appropriateness of organ utilization from cadaver donors with a history of idiopathic thrombocytopenia purpura (ITP) has emerged. Herein is reported a devastating case of TMAT following liver transplantation utilizing an allograft from a donor with ITP that resulted in allograft failure. The literature is reviewed in this context to propose preliminary guidelines regarding utilization of allografts from cadaver donors with a history of ITP.
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