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Updated: Jun 27, 2026

Sulfate Separation by Selective Crystallization with a Bis-iminoguanidinium Ligand
Published on: September 8, 2016
Calcium sulfate: Properties and clinical applications
1Division of Periodontology, University of Kentucky, Lexington, Kentucky, USA. mvthom0@uky.edu
Calcium sulfate (CS), a cost-effective biomaterial, is well-tolerated for bone defect repair and drug delivery. This review highlights its dental applications and potential for bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Applications
Background:
- Calcium sulfate (CS) is a biomaterial with extensive clinical history.
- It is biocompatible, resorbable, and cost-effective.
- CS serves as a versatile vehicle for drug and growth factor delivery.
Purpose of the Study:
- To review the properties and clinical applications of calcium sulfate.
- To emphasize its use in dentistry and bone regeneration.
- To discuss limitations and future research directions.
Main Methods:
- Literature review of calcium sulfate properties and applications.
- Focus on orthopedic and dental uses.
- Analysis of clinical outcomes and material limitations.
Main Results:
- Calcium sulfate demonstrates excellent biocompatibility and resorption without significant inflammation.
- Effective in periodontal defect repair, osteomyelitis treatment, sinus augmentation, and as an adjunct to dental implants.
- Recent resurgence in interest for regenerative applications.
Conclusions:
- Calcium sulfate is a promising, cost-effective biomaterial for bone regeneration, particularly in dentistry.
- Further research is needed to overcome its limitations and expand its applications.
- Its potential as a drug delivery vehicle enhances its therapeutic value.
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