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Measuring Psoriasis Severity at Home
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Mortality in psoriatic arthritis.

D D Gladman1

  • 1University of Toronto, Toronto, Canada. dafna.gladman@utoronto.ca

Clinical and Experimental Rheumatology
|December 17, 2008
PubMed
Summary

Psoriatic arthritis can cause severe joint damage and increased mortality, particularly from cardiovascular and respiratory diseases. Aggressive treatment is crucial to prevent disease progression and improve patient outcomes.

Area of Science:

  • Rheumatology
  • Immunology

Background:

  • Psoriatic arthritis (PsA) is a severe inflammatory condition affecting joints.
  • Significant joint damage can occur early in PsA, within two years of diagnosis.
  • PsA is associated with increased mortality compared to the general population.

Purpose of the Study:

  • To highlight the severity and progression of joint damage in psoriatic arthritis.
  • To identify key predictors of joint damage progression and mortality in PsA patients.
  • To emphasize the importance of aggressive treatment strategies for psoriatic arthritis.

Main Methods:

  • Analysis of data from large patient cohorts (428 and 680 patients).
  • Identification of factors predicting joint damage progression, including polyarticular presentation, disease activity, and existing damage.

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  • Assessment of mortality causes and predictors, such as high sedimentation rate and radiological damage.

    • Main Results:

    • Nearly half of PsA patients experience joint damage progression within two years.
    • Cardiovascular disease is the leading cause of death, followed by respiratory diseases, cancer, and injuries.
    • Higher mortality rates from respiratory disease, cardiovascular disease, and injuries were observed in PsA patients compared to the general population.

    Conclusions:

    • Early and aggressive treatment of psoriatic arthritis is essential.
    • Managing disease activity and preventing joint damage are critical to reduce long-term morbidity and mortality.
    • Understanding predictors of progression and mortality can guide therapeutic decisions in PsA management.