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Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Overview of Systemic Arteries01:11

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

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Related Experiment Video

Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Mortality in systemic vasculitis: a systematic review.

R Phillip1, R Luqmani

  • 1Rheumatology Department, Nuffield Orthopaedic Centre, Oxford, UK.

Clinical and Experimental Rheumatology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Survival rates for systemic vasculitis have improved due to early diagnosis and immunosuppressive therapy. However, mortality remains high in severe cases, emphasizing the need for better interventions to reduce treatment toxicity and comorbidities.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic vasculitis survival has improved with immunosuppressive therapy and earlier diagnosis.
  • Mortality rates vary across different types of vasculitis, including small, medium, and large vessel forms.

Purpose of the Study:

  • To review current mortality risks in patients with various types of systemic vasculitis.
  • To identify factors contributing to early and late deaths in vasculitis patients.

Main Methods:

  • Literature review of published studies on systemic vasculitis mortality.
  • Analysis of survival rates for specific vasculitis subtypes (e.g., ANCA-associated vasculitis, giant cell arteritis).

Main Results:

  • Survival rates at 5 years range from 45% (microscopic polyangiitis) to over 99% (Kawasaki disease).
  • Mortality is decreasing due to effective treatments but remains elevated in severe disease.
  • Early deaths are linked to active vasculitis, organ failure, and infection; late deaths may result from therapy side effects and comorbidities.

Conclusions:

  • Improved early diagnosis and targeted therapy are crucial for reducing mortality and treatment-related complications.
  • Addressing long-term effects of therapy and comorbidities is essential for improving outcomes in systemic vasculitis.