Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fingolimod and risk of skin cancer among individuals with multiple sclerosis: a population-based cohort study protocol.

BMJ open·2025

Same author

Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 115: 2526-2532, 2007.

Clinical journal of the American Society of Nephrology : CJASN·2023

Same author

Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study.

Osteoarthritis and cartilage·2022

Same author

Timing of antibiotics in septic patients: a prospective cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020

Same author

The incidence and seasonal variation of necrotizing fasciitis in Korea: a nationwide cross-sectional study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020

Same author

Association of tramadol with risk of myocardial infarction among patients with osteoarthritis.

Osteoarthritis and cartilage·2019

Search research articles

Related Experiment Videos

Gout and mortality.

S Y Kim¹, M A De Vera, H K Choi

¹Division of Rheumatology, Department of Medicine, University of Pennsylvania, PA, USA.

Clinical and Experimental Rheumatology

|December 17, 2008

Summary

This summary is machine-generated.

Men with gout face a higher risk of death from all causes, primarily due to cardiovascular disease (CVD). Aggressive management of CVD risk factors is recommended for gout patients. Further research in women is needed.

Related Experiment Videos

Area of Science:

Rheumatology
Cardiology
Epidemiology

Background:

Gout is a common inflammatory arthritis.
Cardiovascular disease (CVD) is a leading cause of mortality.
The relationship between gout and overall mortality requires updated insights.

Purpose of the Study:

To review recent data on mortality risks in individuals with gout.
To investigate the association between gout and all-cause mortality.
To explore the contribution of cardiovascular factors to gout-related mortality.

Main Methods:

Analysis of a large prospective study in men.
Review of an extension study from a major clinical trial.
Examination of mortality data in relation to gout diagnosis and uric acid levels.

Main Results:

Gout is associated with an increased risk of all-cause mortality in men.
Cardiovascular disease mortality, particularly coronary heart disease, significantly contributes to this increased risk.
Elevated uric acid levels in gout patients correlate with higher long-term all-cause and CVD mortality.

Conclusions:

Emerging data suggest men with gout have elevated risks of all-cause and CVD mortality.
Aggressive management of cardiovascular risk factors in men with gout is supported.
Further research, including studies on women, is needed to fully elucidate these associations.