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Gout and mortality

S Y Kim1, M A De Vera, H K Choi

  • 1Division of Rheumatology, Department of Medicine, University of Pennsylvania, PA, USA.

Clinical and Experimental Rheumatology
|December 17, 2008
PubMed

Insights

Men with gout face a higher risk of death from all causes, primarily due to cardiovascular disease (CVD). Aggressive management of CVD risk factors is recommended for gout patients. Further research in women is needed.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Gout is a common inflammatory arthritis.
  • Cardiovascular disease (CVD) is a leading cause of mortality.
  • The relationship between gout and overall mortality requires updated insights.

Purpose of the Study:

  • To review recent data on mortality risks in individuals with gout.
  • To investigate the association between gout and all-cause mortality.
  • To explore the contribution of cardiovascular factors to gout-related mortality.

Main Methods:

  • Analysis of a large prospective study in men.
  • Review of an extension study from a major clinical trial.
  • Examination of mortality data in relation to gout diagnosis and uric acid levels.

Main Results:

  • Gout is associated with an increased risk of all-cause mortality in men.
  • Cardiovascular disease mortality, particularly coronary heart disease, significantly contributes to this increased risk.
  • Elevated uric acid levels in gout patients correlate with higher long-term all-cause and CVD mortality.

Conclusions:

  • Emerging data suggest men with gout have elevated risks of all-cause and CVD mortality.
  • Aggressive management of cardiovascular risk factors in men with gout is supported.
  • Further research, including studies on women, is needed to fully elucidate these associations.

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