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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Jun 27, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Mortality in osteoarthritis.

M C Hochberg1

  • 1Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA. mhochber@medicine.umaryland.edu

Clinical and Experimental Rheumatology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) is linked to increased mortality, particularly from cardiovascular and gastrointestinal issues. Factors like OA severity, age, and comorbidities contribute to this elevated risk in OA patients.

Related Experiment Videos

Last Updated: Jun 27, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Area of Science:

  • Rheumatology
  • Epidemiology
  • Gerontology

Background:

  • Mortality in osteoarthritis (OA) patients remains under-investigated.
  • Existing research lacks comprehensive analysis of OA's impact on survival rates.

Purpose of the Study:

  • To systematically review and synthesize evidence on mortality in individuals with osteoarthritis.
  • To identify specific causes of death and risk factors associated with OA.

Main Methods:

  • Systematic review of seven studies, supplemented by two additional articles.
  • Inclusion of studies with radiographic or clinical OA diagnoses.
  • Best evidence synthesis for pooling results.

Main Results:

  • Moderate evidence indicates increased mortality in OA patients compared to the general population.
  • Elevated cause-specific mortality observed for cardiovascular and gastrointestinal disorders.
  • Key risk factors identified: OA burden, advanced age, and comorbidities.

Conclusions:

  • Osteoarthritis is associated with a higher risk of mortality.
  • Reduced physical activity and medication side effects may contribute to excess mortality.
  • Comorbidities significantly influence survival outcomes in OA patients.