Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute misoprostol toxicity.

D J Graber1, K H Meier

  • 1Department of Emergency Medicine, Kaiser Foundation Hospital, Sacramento, California 95825.

Annals of Emergency Medicine
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor necrosis factor-alpha induces changes in mitochondrial cellular distribution in motor neurons.

Neuroscience·2007
Same author

Development of striatal patch/matrix organization in organotypic co-cultures of perinatal striatum, cortex and substantia nigra.

Neuroscience·2001
Same author

The electrocardiogram at extreme altitude: experience on Mt. Everest.

American heart journal·1985
Same author

Relationship of hypoxic ventilatory response to exercise performance on Mount Everest.

Journal of applied physiology: respiratory, environmental and exercise physiology·1984
Same author

Maximal exercise at extreme altitudes on Mount Everest.

Journal of applied physiology: respiratory, environmental and exercise physiology·1983
Same author

The significant asymmetrical tympanogram.

Journal of speech and hearing research·1978
Same journal

Variation in Emergency Department Experience With Pediatric Critical Illness.

Annals of emergency medicine·2026
Same journal

Point-of-Care Ultrasound-Guided Hydrostatic Reduction of Ileocolic Intussusception in the Pediatric Emergency Department.

Annals of emergency medicine·2026
Same journal

Managing Diabetic Ketoacidosis.

Annals of emergency medicine·2026
Same journal

Needle Thoracostomy: Implications of Chest Wall Thickness for Anatomical Location and Needle Length.

Annals of emergency medicine·2026
Same journal

Women Emergency Physicians and Gender Disparities from Entry to Advancement.

Annals of emergency medicine·2026
Same journal

Policy Statements Approved March 2026.

Annals of emergency medicine·2026
See all related articles

Accidental overdose of misoprostol (Cytotec) can cause toxicity, including fever and rapid heart rate. Prompt supportive care led to full recovery in a patient who ingested 15 times the recommended dose.

Area of Science:

  • Pharmacology
  • Gastroenterology

Background:

  • Misoprostol (Cytotec) is a prostaglandin E1 analog.
  • Approved for preventing NSAID-induced gastropathy.
  • Recently released, with limited data on acute toxicity.

Observation:

  • A 71-year-old woman accidentally ingested 3 mg of misoprostol.
  • This dose was approximately 15 times the maximum recommended therapeutic dose.
  • The patient presented with fever, tremor, tachycardia, hypertension, nausea, and abdominal cramping.

Findings:

  • Acute misoprostol overdose can lead to significant toxicity.
  • Symptoms include autonomic and gastrointestinal distress.
  • Standard supportive care is effective for managing acute toxicity.

Related Experiment Videos

Implications:

  • Highlights the potential for toxicity with misoprostol overdose.
  • Informs clinical management of acute misoprostol ingestions.
  • Emphasizes the importance of accurate dosing and patient education.