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Relationship between plasma leptin level and brain structure in elderly: a voxel-based morphometric study.

Kosuke Narita1, Hirotaka Kosaka, Hidehiko Okazawa

  • 1Department of Neuropsychiatry, University of Fukui, Fukui 910-1193, Japan.

Biological Psychiatry
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Higher leptin levels correlate with increased gray matter volume in key brain regions like the hippocampus and cerebellum in older adults, suggesting neuroprotective effects.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Endocrinology

Background:

  • Leptin is increasingly recognized for its roles in synaptic plasticity and neuroprotection within the brain.
  • Evidence suggests a connection between leptin signaling and brain health, particularly during aging.

Purpose of the Study:

  • To investigate the association between plasma leptin levels and gray matter volume in elderly individuals.
  • To explore potential neuroprotective roles of leptin in the aging brain.

Main Methods:

  • A cross-sectional study involving 34 elderly subjects with normal glucose, without dementia or metabolic syndrome.
  • Voxel-based morphometry of magnetic resonance imaging (MRI) scans was used to assess gray matter (GM) volume.
  • Statistical analyses adjusted for age, gender, body mass index (BMI), waist-to-hip ratio (W/H), and intracranial volume.

Main Results:

  • Plasma leptin levels did not correlate with total gray matter volume.
  • A significant positive correlation was observed between leptin levels and GM volumes in the right hippocampus, left parahippocampus, and right cerebellum (adjusted for age, gender, BMI, W/H).
  • Further adjustments for intracranial volume confirmed a positive correlation between leptin and GM volumes in the right hippocampus and bilateral cerebella, but not the left parahippocampus.

Conclusions:

  • This pilot study suggests leptin may have a positive impact on specific brain regions during aging.
  • Findings contribute to understanding leptin's potential neuroprotective effects in the context of human brain aging.