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Alcohol enhances Abeta42-induced neuronal cell death through mitochondrial dysfunction

Do Yeon Lee1, Kyu-Sun Lee, Hyun Jung Lee

  • 1Department of Anatomy and Cell biology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea.

FEBS Letters
|November 26, 2008
PubMed
Summary

Alcohol consumption worsens Alzheimer's disease (AD) by synergistically increasing beta-amyloid (Abeta)-induced neuronal cell death. This occurs through elevated reactive oxygen species (ROS) and mitochondrial dysfunction, highlighting alcohol's detrimental impact on AD progression.

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