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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Published on: November 5, 2010

A novel group of rhinoviruses is associated with asthma hospitalizations

E Kathryn Miller1, Kathryn M Edwards, Geoffrey A Weinberg

  • 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-9500, USA. eva.k.miller@vanderbilt.edu

The Journal of Allergy and Clinical Immunology
|November 26, 2008
PubMed

Insights

New group C human rhinoviruses (HRVCs) cause a significant burden of pediatric disease, particularly in hospitalized children. These novel viruses are frequently associated with asthma and respiratory conditions.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory medicine

Background:

  • Recent identification of new group C human rhinoviruses (HRVCs).
  • Limited understanding of the spectrum of pediatric diseases caused by HRVCs.

Purpose of the Study:

  • To determine the clinical presentation and disease burden of HRVCs in young hospitalized children.
  • Investigate the association between HRVCs and underlying health conditions in pediatric patients.

Main Methods:

  • Prospective population-based surveillance in two US counties (October 2001-September 2003).
  • Enrolled children under 5 years old hospitalized with acute respiratory illness or fever.
  • Utilized RT-PCR and partial sequencing to detect and characterize human rhinoviruses (HRVs), including HRVCs.

Main Results:

  • 167 out of 1052 (16%) children tested positive for HRVs.
  • HRVCs were identified in 77 samples, constituting nearly half of all HRV-associated hospitalizations.
  • Children with HRVCs showed a higher likelihood of underlying asthma (42% vs 23%) and asthma as a discharge diagnosis (55% vs 36%) compared to group A HRVs.

Conclusions:

  • HRVCs are detected in 7% of pediatric hospitalizations for respiratory conditions or fever.
  • HRVCs represent a substantial cause of pediatric disease, particularly among hospitalized children.
  • The findings highlight the significant role of HRVCs in pediatric respiratory illnesses, especially in children with asthma.
Abstract

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