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Published on: October 10, 2013
Poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion polymerization. 2. PEG-based surfactants
M Wu1, E Dellacherie, A Durand
1Laboratoire de Chimie Physique Macromoléculaire, Nancy-Université, CNRS, 1 rue Grandville, B.P. 20451, F-54001 Nancy, France.
Abstract:
This study aimed at synthesizing PEG-coated poly(n-butyl cyanoacrylate) nanoparticles by miniemulsion polymerization. Despite the high reactivity of butyl cyanoacrylate, nanoparticles were successfully obtained by miniemulsion polymerization of butyl cyanoacrylate-in-water emulsions stabilized by three PEG-based surfactants: Brij78, Brij700, and Tween80. Their physico-chemical properties were thoroughly investigated as a function of surfactant structure and concentration and discussed on the basis of results obtained from interfacial tension measurements (dodecane-water). Results clearly showed the influence of the length of the PEG part of the surfactant on the final properties of the particles.
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