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Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors
J D Littlewood1, S A Bevan, G Kemball-Cook
1Department of Clinical Veterinary Medicine, University of Cambridge.
British Journal of Haematology
|April 1, 1991
Abstract:
The source of human factor VIIII (FVIII) had a marked effect on the inhibitory activity of a panel of eight human FVIII inhibitors. Use of conventional FVIII concentrates gave lower inhibitor titres whereas a monoclonal antibody purified FVIII concentrate gave titres similar to or greater than those with plasma. Addition of phospholipid (PL) protected highly purified FVIII against inhibition. The content of PL-bound FVIII in concentrates may account for the observed differences.