Related Experiment Video
Updated: Jun 27, 2026

12:28
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
Acute cerebellitis in identical twins.
Fang Xu1, Shi Qing Ren, Jun Yan Liu
1Department of Neurology, Third Hospital of HeBei Medical University, Shijiazhuang, China.
Pediatric Neurology
|November 26, 2008
Summary
Acute cerebellitis, an inflammatory brain condition, affected identical twin boys sequentially. This case suggests possible viral transmission between the twins, highlighting a rare occurrence of this pediatric neurological disorder.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Background:
- Acute cerebellitis is an inflammatory syndrome causing cerebellar dysfunction, typically in children post-viral infection.
- Cerebellar dysfunction presents with symptoms like ataxia, dysarthria, and nystagmus.
Observation:
- A unique case of identical twin brothers diagnosed with acute cerebellitis.
- The condition manifested in each twin 8 days apart.
Findings:
- Magnetic resonance imaging revealed identical cerebellar lesions in both affected twins.
- This similarity strongly suggests a contagious etiology, likely viral transmission between the siblings.
Implications:
- This case provides novel insight into the potential for person-to-person transmission of the causative agent of acute cerebellitis.
- Understanding transmission routes is crucial for managing and preventing outbreaks of this pediatric neurological condition.
Related Concept Videos
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

