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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Acute cerebellitis in identical twins.

Fang Xu1, Shi Qing Ren, Jun Yan Liu

  • 1Department of Neurology, Third Hospital of HeBei Medical University, Shijiazhuang, China.

Pediatric Neurology
|November 26, 2008
PubMed
Summary

Acute cerebellitis, an inflammatory brain condition, affected identical twin boys sequentially. This case suggests possible viral transmission between the twins, highlighting a rare occurrence of this pediatric neurological disorder.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • Acute cerebellitis is an inflammatory syndrome causing cerebellar dysfunction, typically in children post-viral infection.
  • Cerebellar dysfunction presents with symptoms like ataxia, dysarthria, and nystagmus.

Observation:

  • A unique case of identical twin brothers diagnosed with acute cerebellitis.
  • The condition manifested in each twin 8 days apart.

Findings:

  • Magnetic resonance imaging revealed identical cerebellar lesions in both affected twins.
  • This similarity strongly suggests a contagious etiology, likely viral transmission between the siblings.

Implications:

  • This case provides novel insight into the potential for person-to-person transmission of the causative agent of acute cerebellitis.

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  • Understanding transmission routes is crucial for managing and preventing outbreaks of this pediatric neurological condition.