Related Experiment Video

Updated: Jun 27, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Important factors for salvaging myocardium in patients with acute myocardial infarction

Jun Murakami1, Takuji Toyama, Hitoshi Adachi

  • 1Gunma Prefectural Cardiovascular Center, Division of Cardiology, Gunma 371-0004, Japan. jun-mura@fc4.so-net.ne.jp

Journal of Cardiology
|November 26, 2008
PubMed

Insights

High TIMI grade, prodromal angina, and nicorandil administration improve myocardial salvage after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Distal protection devices were associated with less myocardial salvage.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Nuclear Cardiology

Background:

  • Acute myocardial infarction (AMI) requires prompt intervention to preserve heart muscle.
  • Percutaneous coronary intervention (PCI) is a key treatment for AMI, but myocardial salvage varies.
  • Identifying factors influencing myocardial salvage is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate factors affecting myocardial salvage post-PCI in AMI patients.
  • To identify clinical variables associated with improved or diminished myocardial salvage.

Main Methods:

  • Recruited 183 AMI patients who underwent successful PCI.
  • Utilized technetium-99m pyrophosphate and sestamibi SPECT imaging on days 3 and 6.
  • Calculated myocardial salvage rate using summed defect and extent scores via multivariate analysis.

Main Results:

  • Nicorandil administration, prodromal angina, and high TIMI grade positively correlated with myocardial salvage rate (p=0.006, p<0.001, p<0.001).
  • Distal protection device use showed a negative correlation with myocardial salvage rate (p=0.006).

Conclusions:

  • High TIMI grade and prodromal angina are critical for myocardial salvage in AMI.
  • Nicorandil administration significantly aids myocardial salvage post-PCI.
Abstract

More Related Videos

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in G&#246;ttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice08:03

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

Related Concept Videos

Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...