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Updated: Jun 27, 2026
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Interleukin 17-producing T helper cells in alloimmunity
Fleur Samantha Benghiat1, Louis Marie Charbonnier, Benoit Vokaer
1Institute for Medical Immunology, Université Libre de Bruxelles, 6041 Gosselies, Belgium. fbenghia@ulb.ac.be
Transplantation Reviews (Orlando, Fla.)
|November 26, 2008
Summary
Interleukin 17 (IL-17) may drive allograft rejection through a distinct T helper 17 (Th17) cell pathway. This pathway involves complex interactions between regulatory T cells and Th17 cells in the context of organ transplantation.
Area of Science:
- Immunology
- Transplantation immunology
Background:
- Interleukin 17 (IL-17) is a pro-inflammatory cytokine involved in host defense and autoimmune diseases.
- IL-17 is produced by various immune cells, including a distinct subset of CD4+ T helper cells known as Th17 cells.
Purpose of the Study:
- To explore the potential role of Th17 cells in allograft rejection.
- To review existing clinical and experimental data supporting a Th17-mediated rejection pathway.
- To examine the interplay between regulatory T cells and Th17 cells in allogeneic responses.
Main Methods:
- Literature review of clinical and experimental studies on IL-17 and T cell subsets in transplantation.
- Analysis of observations related to Th17 cell function in allograft rejection.
- Discussion of regulatory T cell and Th17 cell interactions in the allogeneic setting.
Main Results:
- Evidence suggests that Th17 cells may represent an alternative pathway for allograft rejection.
- The balance between regulatory T cells and Th17 cells is crucial in modulating allogeneic responses.
Conclusions:
- Th17 cells are implicated as a significant factor in allograft rejection.
- Understanding the Th17 pathway and its regulation offers potential therapeutic targets for improving transplant outcomes.
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