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Updated: Jun 27, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
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Published on: December 20, 2024

Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method

Takuya Arai1, Ming-Rong Zhang, Masanao Ogawa

  • 1Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|November 26, 2008
PubMed
Summary

Researchers developed a new method to synthesize [1-(11)C]Acetyl chloride using carbon dioxide and methylmagnesium bromide. This novel approach yields radiolabeled phenylacetate and benzylacetate with high purity for potential applications.

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