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Updated: Jun 27, 2026

Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
Published on: October 6, 2019
No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis
Sabine Vollstedt1, Rika Yuliwulandari, Koji Okamoto
1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.
Abstract:
Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned out not to be associated with pulmonary tuberculosis.
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