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Updated: Jun 27, 2026
07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Antihistamine therapy and bone mineral density: analysis in a population-based US sample
Mitsuyo Kinjo1, Soko Setoguchi, Daniel H Solomon
1Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan. mitsuyos220@worldnet.att.net
The American Journal of Medicine
|November 26, 2008
Summary
Histamine receptor antagonists show varied effects on bone density. Histamine 1 receptor antagonist use was linked to higher bone mineral density, while histamine 2 receptor antagonist use was associated with lower bone mineral density, especially with low calcium intake.
Area of Science:
- Pharmacology
- Bone Metabolism
- Gerontology
Background:
- Histamine's role in bone turnover is significant but not fully understood.
- Limited human data exists on the effects of histamine receptor antagonists (HRAs) on bone mineral density (BMD).
Purpose of the Study:
- To investigate the association between histamine 1 receptor antagonist (H1RA) and histamine 2 receptor antagonist (H2RA) use and femoral neck bone mineral density (BMD) in older adults.
- To analyze BMD differences in HRA users versus non-users within a US population-based sample.
Main Methods:
- Utilized data from the Third National Health and Nutrition Examination Survey (1988-1994).
- Included adult subjects aged 60+ who underwent dual energy x-ray absorptiometry.
- Employed adjusted linear regression models accounting for osteoporosis risk factors.
Main Results:
- H1RA users exhibited slightly higher adjusted femoral neck BMD (0.74 g/cm²) compared to non-users (0.72 g/cm²; P=.037).
- H2RA users showed significantly lower adjusted BMD (0.69 g/cm²) versus non-users (0.72 g/cm²; P=.003).
- The negative association between H2RA use and BMD was not observed when daily calcium intake exceeded 800 mg.
Conclusions:
- H1RA use may be associated with increased femoral neck BMD in older adults.
- H2RA use, particularly with low calcium intake, is linked to reduced bone mineral density in the elderly.
- Further research is warranted to elucidate the mechanisms underlying these associations.
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