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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: Jun 27, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Osteoporosis in men.

Jean M Kaufman¹, Stefan Goemaere

¹Ghent University Hospital, Department of Endocrinology, Gent, Belgium. jean.kaufman@ugent.be

Best Practice & Research. Clinical Endocrinology & Metabolism

|November 26, 2008

Summary

Osteoporotic fractures in men are severe, yet underdiagnosed and undertreated. Risk assessment should guide treatment decisions due to limited long-term therapy data.

Area of Science:

Endocrinology
Bone Metabolism
Geriatrics

Background:

Osteoporotic fractures represent a significant health burden for men, with severe consequences.
Current detection and treatment rates for high-risk men remain insufficient.
A lack of consensus definition for osteoporosis in men complicates diagnosis.

Purpose of the Study:

To highlight the underdiagnosis and undertreatment of osteoporosis in men.
To emphasize the importance of absolute fracture risk assessment for therapeutic decisions.
To review the role of estradiol and different osteoporosis types in men.

Main Methods:

Review of existing literature on male osteoporosis, fracture risk, and therapeutic options.
Analysis of factors influencing bone mineral density (BMD) and fracture risk in men.

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Last Updated: Jun 27, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Consideration of secondary osteoporosis and age-related bone loss.

Main Results:

Absolute fracture risk, incorporating age, BMD, and clinical factors, is crucial for management.
Idiopathic and senile osteoporosis have distinct underlying mechanisms in men.
Estradiol plays a key role in bone maturation and metabolism.

Conclusions:

Therapeutic decisions for male osteoporosis should be individualized based on comprehensive fracture risk assessment.
Limited long-term data exists for osteoporosis therapies in men, necessitating cautious application.
Clinical judgment and careful risk estimation are paramount when initiating treatment.