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03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Hypereosinophilic syndromes.
Jean-Emmanuel Kahn1, Olivier Blétry, Loïc Guillevin
1French Eosinophil Network, Department of Immunology, CHRU de Lille, Université Lille, Lille, France.
Best Practice & Research. Clinical Rheumatology
|November 26, 2008
Summary
Hypereosinophilia, an elevated eosinophil count, can stem from various conditions. If an underlying cause isn't found, hypereosinophilic syndrome (HES) or Churg-Strauss syndrome (CSS) may be diagnosed.
Area of Science:
- Hematology
- Immunology
- Internal Medicine
Background:
- Hypereosinophilia is a frequent clinical observation.
- It often indicates an underlying pathological condition.
- Common causes include infections, allergies, drug reactions, organ-specific diseases, malignancies, and systemic disorders.
Purpose of the Study:
- To define the diagnostic pathway for hypereosinophilia.
- To identify conditions that mimic or lead to hypereosinophilic syndrome (HES).
- To clarify the diagnostic criteria for HES and Churg-Strauss syndrome (CSS).
Main Methods:
- Review of clinical findings associated with hypereosinophilia.
- Evaluation of diagnostic workups for patients with persistent hypereosinophilia.
- Differential diagnosis of conditions presenting with elevated eosinophil counts.
Main Results:
- Hypereosinophilia (>0.5x10(9)/L) is a significant hematological finding.
- A broad spectrum of diseases can cause secondary hypereosinophilia.
- Persistent hypereosinophilia without an identified cause suggests HES or CSS.
Conclusions:
- A comprehensive evaluation is crucial for identifying the cause of hypereosinophilia.
- Hypereosinophilic syndrome (HES) and Churg-Strauss syndrome (CSS) are diagnoses of exclusion.
- These syndromes are considered when other causes of chronic hypereosinophilia are ruled out.
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