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Solid versus liquid lithium--a pharmacokinetic study.

H R Markar1, G Ascough

  • 1Department of Psychiatry, Addenbrooke's Hospital, University of Cambridge, U.K.

Journal of Clinical Pharmacy and Therapeutics
|February 1, 1991
PubMed
Summary
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Solid lithium (Priadel) and liquid lithium citrate show similar 12-hour steady-state levels but differ significantly in absorption rate and degree. These pharmacokinetic differences have clinical implications for manic depressive patients.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Clinical Pharmacy

Background:

  • Lithium is a cornerstone mood stabilizer for bipolar disorder.
  • Different formulations of lithium exist, including solid and liquid forms.
  • Understanding pharmacokinetic differences is crucial for therapeutic efficacy.

Purpose of the Study:

  • To compare the pharmacokinetics of solid lithium (Priadel) and liquid lithium citrate.
  • To assess differences in absorption rate and degree between the two lithium preparations.

Main Methods:

  • A pharmacokinetic study was conducted.
  • Nine manic depressive patients participated in the study.
  • Steady-state lithium levels were measured over 12 hours.

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Main Results:

  • Both solid and liquid lithium preparations achieved similar 12-hour steady-state levels.
  • Significant differences were observed in the rate and extent of lithium absorption between the two formulations.

Conclusions:

  • Despite similar steady-state concentrations, the absorption profiles of solid and liquid lithium differ.
  • These pharmacokinetic variations may have clinical implications for managing bipolar disorder.
  • Further discussion on clinical implications is warranted.