Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Stress Prevention and Stress Management Techniques IV01:26

Stress Prevention and Stress Management Techniques IV

Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vulvar findings and sexual dysfunction in women with systemic sclerosis.

JAAD international·2026
Same author

Relevance of Systematic Pre-Biologic Infectious Screening in Chronic Inflammatory Rheumatic Diseases: A Retrospective Single-Center Study.

Journal of clinical medicine·2026
Same author

Women with spondyloarthritis occurring in the peripartum period develop a singular phenotype.

BMC musculoskeletal disorders·2026
Same author

Condensation of the lower part of the iliac bone.

Joint bone spine·2026
Same author

Artificial Intelligence in Rheumatology: From Algorithms to Clinical Impact in Osteoporosis and Chronic Inflammatory Rheumatic Diseases.

Journal of clinical medicine·2026
Same author

Joint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort.

RMD open·2025
Same journal

The young adult with Juvenile Idiopathic Arthritis (JIA): A clinical review of transition, complications, and psychosocial management.

Best practice & research. Clinical rheumatology·2026
Same journal

Impact of fatigue on rheumatic diseases: Current perspectives.

Best practice & research. Clinical rheumatology·2026
Same journal

Pneumocystis prophylaxis in rheumatic disease.

Best practice & research. Clinical rheumatology·2026
Same journal

Cutaneous manifestations in myositis syndromes.

Best practice & research. Clinical rheumatology·2026
Same journal

Systemic sclerosis: A comprehensive systematic review of global epidemiology, sex and ethnic disparities, disease burden, and organ-specific involvement.

Best practice & research. Clinical rheumatology·2026
Same journal

Alopecia across the spectrum of rheumatic disease.

Best practice & research. Clinical rheumatology·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Smoking and inflammatory diseases.

Olivier Vittecoq1, Thierry Lequerré, Vincent Goëb

  • 1Department of Rheumatology, Rouen University Hospital & Inserm U905, Rouen, France. olivier.vittecoq@chu-rouen.fr

Best Practice & Research. Clinical Rheumatology
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Smoking significantly impacts rheumatoid arthritis (RA) and lupus development and outcomes. It

More Related Videos

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
09:25

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Published on: January 10, 2015

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells
09:15

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells

Published on: May 11, 2020

Related Experiment Videos

Last Updated: Jun 27, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
09:25

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Published on: January 10, 2015

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells
09:15

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells

Published on: May 11, 2020

Area of Science:

  • Rheumatology
  • Immunology
  • Environmental Health

Background:

  • Smoking is a known environmental risk factor for autoimmune diseases.
  • Rheumatoid arthritis (RA) and lupus (systemic lupus erythematosus) are chronic autoimmune conditions with complex etiologies.
  • The interplay between genetic predisposition and environmental factors like smoking is crucial in disease pathogenesis.

Purpose of the Study:

  • To elucidate the specific associations between smoking and the development and clinical manifestations of rheumatoid arthritis (RA) and lupus.
  • To investigate the interaction of smoking with genetic factors, including HLA-DRB1 shared epitope (SE) alleles and PTPN22 polymorphisms, in RA.
  • To assess the influence of smoking on extra-articular manifestations, radiographic outcomes, and drug efficacy in RA and lupus.

Main Methods:

  • Review and synthesis of existing epidemiological and genetic studies on smoking in RA and lupus.
  • Analysis of associations between smoking status, rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP2) antibody positivity in RA.
  • Examination of the correlation between smoking and human leukocyte antigen (HLA) genotypes, PTPN22 polymorphisms, and disease-specific outcomes in both conditions.

Main Results:

  • Smoking is linked to anti-CCP2-positive RA, particularly in heavy smokers with HLA-DRB1 SE alleles, though this interaction varies geographically.
  • No interaction was found between smoking and PTPN22 1858T genotype in RA development.
  • Smoking is associated with extra-articular manifestations (nodules, cardiovascular events) in RA but not radiographic progression. In lupus, smoking affects anti-double-stranded deoxyribonucleic acid (dsDNA) antibody production and potentially disease development and severity.

Conclusions:

  • Smoking is a significant environmental factor influencing the immunopathogenesis and clinical phenotype of RA and lupus.
  • Genetic factors, such as HLA-DRB1 SE alleles, modulate the risk of smoking-related RA.
  • Smoking may impair treatment efficacy in both RA and lupus and contributes to specific disease manifestations, highlighting the importance of smoking cessation.