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Dermatologic symptoms associated with the multikinase inhibitor sorafenib

Caroline Robert1, Christina Mateus, Alain Spatz

  • 1Department of Medicine, Dermatology Unit, Institut Gustave Roussy, Villejuif, France. crobert@igr.fr

Journal of the American Academy of Dermatology
|November 26, 2008
PubMed
Abstract

Insights

Sorafenib (Nexavar) commonly causes skin issues like rash and hand-foot reactions. However, these dermatologic symptoms are manageable with interventions and preventative care.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Sorafenib (Nexavar), a multikinase inhibitor, frequently causes dermatologic side effects.
  • Understanding these side effects is crucial for patient management in advanced solid tumors.

Purpose of the Study:

  • To evaluate and guide the diagnosis and clinical management of sorafenib-induced dermatologic symptoms.
  • Focus on patients with advanced solid tumors receiving single-agent sorafenib.

Main Methods:

  • Systematic review of English-language studies.
  • Emphasis on the phase III Treatment Approaches in Renal Cancer Global Evaluation Trial (TARGETs).

Main Results:

  • Common sorafenib dermatologic side effects include rash/desquamation (40%), hand-foot skin reaction (30%), alopecia (27%), and pruritus (19%).
  • Most symptoms resolve with management strategies like topical treatments, dose adjustments, or combined approaches.

Conclusions:

  • Sorafenib-associated dermatologic symptoms are common but generally manageable.
  • Effective intervention, patient self-care, and preventative measures lead to symptom resolution.

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