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Updated: Jun 27, 2026
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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Adipokines and sublingual immunotherapy: preliminary report
Giorgio Ciprandi1, Mara De Amici, Giuseppe Murdaca
1Department of Internal Medicine, University of Genoa, Italy.
Human Immunology
|November 26, 2008
Summary
This study investigated serum adipokines in allergic rhinitis patients before and after sublingual immunotherapy (SLIT). A single SLIT course did not significantly alter leptin or adiponectin levels, though some correlations with clinical factors were observed.
Area of Science:
- Immunology
- Allergology
- Metabolic Research
Background:
- Increased Body Mass Index (BMI) is linked to respiratory allergies like asthma and rhinitis.
- Serum adipokines, including leptin and adiponectin, may be elevated in allergic rhinitis patients.
Purpose of the Study:
- To assess serum leptin and adiponectin levels in pollen-induced allergic rhinitis patients.
- To evaluate changes in these adipokines before and after sublingual immunotherapy (SLIT).
Main Methods:
- A cohort of 41 allergic rhinitis patients and 34 controls were studied.
- Serum adipokines, IgE, and eosinophils were measured before and after a single SLIT course.
- Statistical analysis explored correlations between adipokines, clinical parameters, and eosinophils.
Main Results:
- A slight, non-significant increasing trend in both adipokines was observed post-SLIT, with gender differences noted.
- Leptin correlated significantly with clinical parameters and eosinophils.
- Adiponectin showed an inverse correlation with eosinophils in men only.
Conclusions:
- A single preseasonal SLIT course does not significantly alter serum adipokine levels in allergic rhinitis patients.
- Preliminary findings suggest potential gender-specific relationships between adipokines and clinical markers.
