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07:08
The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Differential responses to mutagens among human lymphocyte subpopulations
Huachun Weng1, Kanehisa Morimoto
1Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Osaka 565-0871, Japan.
Mutation Research
|November 26, 2008
Summary
This review clarifies confusing data on lymphocyte subpopulation sensitivity to mutagens. It identifies specific cells, like T-cells and B-cells, most responsive to genotoxic agents for biomonitoring.
Area of Science:
- Immunotoxicology
- Genetic Toxicology
- Biomonitoring
Background:
- Differential responses of human lymphocyte subpopulations to mutagens are documented.
- Conflicting data exists regarding mutagen sensitivity across lymphocyte subsets.
Purpose of the Study:
- To review existing literature on mutagenic responses in CD4+ T-cells, CD8+ T-cells, B-cells, and NK-cells.
- To clarify differential sensitivity of lymphocyte subpopulations to various mutagens.
Main Methods:
- Literature review of studies using micronuclei (MN), sister chromatid exchanges (SCEs), single cell gel electrophoresis (SCGE), and fluorescence-activated cell sorting (FACS).
- Analysis of data on CD4+ T-cells, CD8+ T-cells, B-cells, and NK-cells exposed to mutagens.
Main Results:
- Identified varying sensitivities of lymphocyte subpopulations to different mutagens.
- Highlighted the utility of specific assays for detecting these differential responses.
Conclusions:
- This review provides a reference for identifying sensitive target cells in human populations.
- Findings support enhanced genetic biomonitoring strategies for mutagen exposure.
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