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Published on: January 28, 2020

Prognostic value of circulating chromogranin A levels in acute coronary syndromes

Anna M Jansson1, Helge Røsjø, Torbjørn Omland

  • 1Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

European Heart Journal
|November 26, 2008
PubMed

Insights

Chromogranin A (CgA) levels predict long-term mortality and heart failure hospitalizations in acute coronary syndromes (ACSs). This biomarker offers valuable prognostic information beyond traditional risk factors.

Area of Science:

  • Cardiology
  • Biomarkers
  • Prognostics

Background:

  • Acute coronary syndromes (ACSs) represent a spectrum of clinical presentations of myocardial infarction.
  • Accurate risk stratification is crucial for managing ACS patients and improving outcomes.
  • Conventional risk markers may not fully capture the complexity of patient prognosis.

Purpose of the Study:

  • To investigate the prognostic value of circulating chromogranin A (CgA) levels in patients with ACS.
  • To determine if CgA provides independent prognostic information beyond established cardiovascular risk factors.

Main Methods:

  • A cohort of 1268 ACS patients had their baseline CgA levels measured.
  • Patients were followed for a median of 92 months for mortality and clinical events.
  • Statistical analyses, including adjustments for conventional risk markers, were performed.

Main Results:

  • Elevated CgA levels were strongly associated with increased long-term mortality and heart failure hospitalizations.
  • The association between CgA and mortality remained significant after adjusting for conventional risk factors.
  • CgA also independently predicted heart failure hospitalizations, but not recurrent myocardial infarction or stroke.

Conclusions:

  • Circulating chromogranin A is an independent predictor of long-term mortality and heart failure hospitalizations in ACS patients.
  • CgA offers incremental prognostic value, enhancing risk prediction beyond traditional cardiovascular risk markers.
Abstract

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