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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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Related Experiment Video

Updated: Jun 27, 2026

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Published on: December 13, 2019

Wnt signaling and stem cell control.

R Nusse¹, C Fuerer, W Ching

¹Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Cold Spring Harbor Symposia on Quantitative Biology

|November 26, 2008

Summary

This summary is machine-generated.

Stem cells rely on environmental signals within their niche for self-renewal and differentiation. This study explores how Wnt signaling modifications regulate these signals, impacting stem cell niches.

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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

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Last Updated: Jun 27, 2026

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Published on: December 13, 2019

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Area of Science:

Stem cell biology
Cell signaling
Developmental biology

Background:

Stem cell fate (self-renewal and differentiation) is regulated by environmental signals within a niche.
A proposed model suggests stem cells compete for limited growth factors in the niche.
The range and concentration of these niche factors are critical for maintaining stem cell populations.

Purpose of the Study:

To investigate mechanisms of signal regulation at the level of signal-producing cells within the stem cell niche.
To emphasize the role of biochemical properties and posttranslational modifications in Wnt signaling.
To explore how these modifications establish stem cell niches across various tissues.

Main Methods:

Focus on biochemical properties of signaling molecules.
Analysis of posttranslational modifications of signals.
Examination within the context of Wnt signaling pathways.

Main Results:

Identified specific self-renewing factors involved in stem cell regulation.
Demonstrated that modifications control the range of Wnt signaling.
Established a link between Wnt signal modifications and niche formation.

Conclusions:

Posttranslational modifications of Wnt signals are critical for regulating their range.
These modifications play a key role in establishing functional stem cell niches.
Understanding these mechanisms advances the niche model for stem cell regulation.