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Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass

K Svennevig1, Tn Hoel, As Thiara

  • 1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. katja.svennevig@medisin.uio.no

Perfusion
|November 26, 2008
PubMed

Insights

Plasma syndecan-1 levels significantly increase during coronary artery bypass grafting (CABG), regardless of cardiopulmonary bypass (CPB) use. These findings highlight syndecan-1 as a marker for endothelial glycocalyx shedding in cardiac surgery patients.

Area of Science:

  • Cardiovascular Surgery
  • Endothelial Biology
  • Biomarker Research

Background:

  • The endothelial glycocalyx, a protective layer on blood vessel surfaces, is shed during ischemia and reperfusion.
  • Increased circulating syndecan-1, a key glycocalyx component, indicates endothelial damage.
  • Coronary artery bypass grafting (CABG) involves periods of ischemia and reperfusion, potentially affecting the glycocalyx.

Purpose of the Study:

  • To compare plasma levels of syndecan-1 in patients undergoing CABG with or without cardiopulmonary bypass (CPB).
  • To investigate the impact of CPB on endothelial glycocalyx shedding during CABG.

Main Methods:

  • Plasma syndecan-1 concentrations were measured in two groups of CABG patients: on-pump (n=22) and off-pump (n=22).
  • Measurements were taken at baseline and at specific time points during the surgical procedure.
  • Statistical analysis was performed to compare syndecan-1 levels between groups and over time.

Main Results:

  • Syndecan-1 plasma concentrations increased significantly from baseline in both on-pump and off-pump CABG groups (p < 0.01).
  • Peak syndecan-1 levels were comparable between patients undergoing on-pump and off-pump procedures.
  • The study demonstrated a significant increase in plasma syndecan-1 during CABG, irrespective of CPB utilization.

Conclusions:

  • Plasma syndecan-1 levels rise significantly during CABG surgery, indicating endothelial glycocalyx shedding.
  • The use of cardiopulmonary bypass does not appear to significantly alter the extent of syndecan-1 elevation compared to off-pump procedures.
  • Syndecan-1 serves as a potential biomarker for endothelial injury in patients undergoing CABG, regardless of surgical technique.

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