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Updated: Jun 27, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Peripheral B cell abnormalities and disease activity in systemic lupus erythematosus
A Hostmann1, A M Jacobi, H Mei
1Charite, University Hospital Berlin, Berlin, Germany.
Lupus
|November 26, 2008
Summary
Autoreactive B cells drive systemic lupus erythematosus (SLE) pathogenesis through autoantibodies. Abnormalities in B cell and plasma cell compartments correlate with SLE disease activity, influenced by extrinsic and intrinsic factors.
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies.
- Autoreactive B cells and plasma cells are crucial in SLE pathogenesis.
- Abnormalities within B cell and plasma cell compartments are observed in human SLE.
Purpose of the Study:
- To review recent findings on B cell and plasma cell disturbances in human SLE.
- To discuss cellular abnormalities correlating with SLE disease activity.
- To explore potential extrinsic and intrinsic factors driving B cell activation in SLE.
Main Methods:
- This is a review article, synthesizing existing research.
- Analysis of current literature on B cell and plasma cell biology in SLE.
- Correlation of cellular disturbances with clinical disease activity.
Main Results:
- Specific cellular disturbances in B cell and plasma cell compartments are identified in SLE patients.
- These disturbances partially correlate with disease activity.
- Potential extrinsic and intrinsic factors contributing to B cell activation are highlighted.
Conclusions:
- Autoreactive B cells and plasma cells play a central role in SLE.
- Understanding cellular abnormalities and their drivers is key to managing SLE.
- Further research into extrinsic and intrinsic influences may reveal therapeutic targets.
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