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Bacterial Meningitis

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Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...

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Updated: Jun 27, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

Osteomyelitis due to BCG vaccination.

Parviz Tabatabaie¹, Fatemeh Mahjoub, Mehrzad Mehdizadeh

¹Department of Pediatric Infectious Disease, Children Medical Center, No 62, Dr Gharib Street, Keshavarz Boulevard, Tehran, Iran.

Indian Pediatrics

|November 26, 2008

Summary

A six-month-old boy developed disseminated BCG infection due to Mycobacterium bovis. Prompt antitubercular therapy and surgery led to a full recovery without lasting effects.

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Published on: January 31, 2018

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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

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Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System

Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System

Published on: January 31, 2018

Area of Science:

Pediatric Infectious Diseases
Mycobacterial Infections
Vaccine-Induced Complications

Background:

Bacille Calmette-Guérin (BCG) vaccination is standard for tuberculosis prevention.
Disseminated BCG infection is a rare but serious complication.
Immunocompetent individuals can still develop adverse BCG reactions.

Observation:

A six-month-old boy presented with multiple abscesses and wound infection post-BCG vaccination.
Radiographs showed an osteolytic lesion in the humerus.
Biopsy confirmed a chronic granulomatous lesion positive for Mycobacterium bovis.

Findings:

The patient was diagnosed with disseminated BCG infection caused by M. bovis.
Treatment involved antitubercular therapy and surgical intervention.
Complete resolution of lesions was achieved.

Implications:

This case highlights the importance of recognizing disseminated BCG infection in infants.
Early diagnosis and combined treatment are crucial for favorable outcomes.
It underscores the need for vigilance even in immunocompetent populations.