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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
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Cancer Therapies

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Association of Cumulative Proton Pump Inhibitor Use with Prostate Cancer Risk and Outcomes: A Population-Based Cohort Study.

Cancer research communications·2026
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.

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MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

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Related Experiment Video

Updated: Jun 17, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Reflecting on 25 years with MYC.

Natalie Meyer1, Linda Z Penn

  • 1Amgen Canada, Inc Mississauga, Ontario, Canada.

Nature Reviews. Cancer
|November 26, 2008
PubMed
Summary

MYC, a gene linked to cancer, has been extensively studied for over 25 years. Research into its regulation and function significantly advances our understanding of molecular oncogenesis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The MYC gene, a human homologue of a retroviral oncogene, was identified over 25 years ago.
  • Intense research has followed its discovery, yielding significant insights.

Purpose of the Study:

  • To chronicle major advances in understanding MYC biology.
  • To explore the future directions of MYC research.

Main Methods:

  • Literature review and synthesis of key findings in MYC research.
  • Analysis of the impact of MYC discoveries on broader biological disciplines.

Main Results:

  • Incremental insights into MYC regulation and function have profoundly impacted molecular oncogenesis.
  • MYC research has demonstrated broad applicability across various biological fields.

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

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Related Experiment Videos

Last Updated: Jun 17, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research
09:12

High-Throughput Automated Multiplex Immunofluorescence Assays for Translational Research

Published on: June 10, 2025

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Conclusions:

  • Continued investigation into MYC biology is crucial for advancing cancer research.
  • Future research will likely uncover further implications of MYC in biological processes and disease.