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Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
Published on: June 13, 2025
[Hemolytic uremic syndrome caused by enterohaemorrhagic Escherichia coli]
Cristina Ibarra1, Jorge Goldstein, Claudia Silberstein
1Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, UBA. ibarra@fmed.uba.ar
Abstract:
Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, plaquetopenia and kidney damage. It is the leading cause of acute renal failure in pediatric age and the second for chronic renal failure. Shiga toxin-producing Escherichia coli (STEC) is the first etiologic agent of HUS being its main reservoir cattle and transmitted via contaminated food. At present, there is no specific treatment to reduce the progression of HUS. The study of the mechanisms by which STEC infects and Shiga toxin induces HUS can help to find new strategies to prevent this disease.
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