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Phenytoin toxicity due to genetic polymorphism.

Lauren K McCluggage1, Stacy A Voils, Malcolm Ross Bullock

  • 1Department of Pharmacy Practice and Pharmacy Administration, University of the Sciences in Philadelphia, Philadelphia, PA, USA.

Neurocritical Care
|November 26, 2008
PubMed
Summary

Genetic variations in cytochrome P450 2C9 can lead to phenytoin toxicity in traumatic brain injury patients. Monitoring drug levels is crucial, especially when pharmacogenomic testing is unavailable.

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