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Late-onset tumefactive multiple sclerosis

Taizo Takeuchi1, Mitsuhiro Ogura, Morio Sato

  • 1Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8510, Japan.

Radiation Medicine
|November 26, 2008
PubMed

Insights

Late-onset multiple sclerosis (MS) can occur in elderly patients, even presenting at 87 years old. Tumefactive MS lesions mimic brain tumors, highlighting the need for broad differential diagnoses in older adults.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Demyelinating Diseases

Background:

  • Multiple Sclerosis (MS) is typically diagnosed in younger adults.
  • Tumefactive demyelinating lesions are rare, large MS lesions.
  • Late-onset MS (LOMS) presents diagnostic challenges.

Observation:

  • An 87-year-old patient presented with symptoms fulfilling revised International Panel on MS (2001) criteria.
  • The patient exhibited a tumefactive demyelinating lesion.
  • The lesion showed minimal mass effect and edema, resembling a brain tumor.

Findings:

  • This case demonstrates that multiple sclerosis can manifest at any age.
  • Late-onset MS is a viable diagnosis in the elderly population.
  • Tumefactive lesions in elderly patients warrant consideration for MS.

Implications:

  • MS diagnosis should not be limited by age, even in octogenarians.
  • Tumefactive lesions in the elderly require careful differential diagnosis, including MS.
  • Increased awareness of LOMS can improve timely diagnosis and management.

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