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Collagens in the developing and diseased nervous system.

T Hubert¹, S Grimal, P Carroll

¹INSERM U-583, Institut des Neurosciences de Montpellier, Hôpital Saint-Eloi, 80 Rue Augustin Fliche, 34091 Montpellier Cedex 5, France.

Cellular and Molecular Life Sciences : CMLS

|November 26, 2008

Summary

Collagens, crucial extracellular proteins, play vital roles in the nervous system, particularly during neural development and in response to disease. Their functions extend beyond connective tissues to neural guidance and cell differentiation.

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Area of Science:

Neuroscience
Molecular Biology
Biochemistry

Background:

Collagens are a diverse group of extracellular matrix proteins forming triple helix structures.
While well-studied in connective tissues, their roles in the nervous system are less understood.
Collagens are typically found in peripheral nervous system structures rather than near neuronal cell bodies.

Purpose of the Study:

To review the significant advances in understanding collagen function within the nervous system.
To highlight the importance of collagens in neural development and disease.
To consolidate current knowledge on the diverse roles of collagens in neural tissues.

Main Methods:

This review synthesizes findings from recent research studies.
It integrates data from investigations into neural development and neuropathology.
The summary is based on established literature concerning extracellular matrix molecules.

Main Results:

Collagens are essential during neural development, influencing axonal guidance, synapse formation, and Schwann cell differentiation.
In pathological conditions, collagens provide insights into brain function and dysfunction.
Despite their 'marginal' location, collagens are integral to nervous system architecture and processes.

Conclusions:

Collagens are critical components of the nervous system, impacting development, function, and disease.
Further research into neural collagens will illuminate novel therapeutic targets.
Understanding these extracellular proteins is key to advancing neuroscience.