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Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
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Adiponectin multimers in maternal plasma.

S Mazaki-Tovi1, R Romero, J P Kusanovic

  • 1Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI 48201, USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Pregnancy alters adiponectin multimers, increasing high molecular weight (HMW) adiponectin and decreasing low molecular weight (LMW) adiponectin. Maternal weight also impacts these changes, with normal weight pregnant women showing higher adiponectin levels than overweight women.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Reproductive Biology

Background:

  • Adiponectin, an adipokine, exists in various molecular weight complexes (LMW, MMW, HMW).
  • These complexes have distinct biological activities, influencing metabolic and vascular health.
  • Understanding adiponectin multimer dynamics is crucial for metabolic and pregnancy-related research.

Purpose of the Study:

  • To investigate changes in adiponectin multimer distribution during pregnancy.
  • To examine the influence of maternal body mass index (BMI) on adiponectin isoforms in pregnant women.
  • To compare adiponectin profiles between pregnant and non-pregnant women.

Main Methods:

  • Cross-sectional study design involving pregnant and non-pregnant women.
  • Plasma adiponectin levels (total, HMW, MMW, LMW) measured using ELISA.
  • Participants categorized by BMI into normal weight and overweight groups.

Main Results:

  • Pregnant women exhibited higher HMW adiponectin and HMW/total ratio, with lower LMW adiponectin compared to non-pregnant women.
  • Normal weight pregnant women had higher total, HMW, and MMW adiponectin concentrations than overweight pregnant women.
  • HMW adiponectin was the predominant isoform, irrespective of gestational age or BMI.

Conclusions:

  • Human pregnancy is associated with significant quantitative and qualitative alterations in adiponectin multimers.
  • The high molecular weight (HMW) adiponectin isoform shows particular changes during pregnancy.
  • Maternal weight status influences adiponectin multimer profiles in pregnancy.