Related Experiment Video
Updated: Jun 27, 2026

In vivo Measurement of Knee Extensor Muscle Function in Mice
Published on: March 4, 2021
One-repetition maximum strength test represents a valid means to assess leg strength in vivo in humans
Lex B Verdijk1, Luc van Loon, Kenneth Meijer
1Department of Human Movement Sciences, Maastricht University, Maastricht, Netherlands. lex.verdijk@bw.unimaas.nl
Abstract:
Skeletal muscle strength is often determined to evaluate the adaptive response to an exercise intervention programme. Although dynamometry is considered the "gold standard" for the assessment of muscle strength in vivo, one-repetition maximum (1-RM) testing performed on training-specific equipment is more commonly applied. We assessed the validity of specific knee extension 1-RM testing by comparison with dynamometry in a heterogeneous population (n=55). All participants performed 1-RM tests on regular leg extension and leg press machines. Additionally, isometric (at seven different knee angles) and isokinetic (at four different velocities) knee extension peak torques were determined. Pearson's r was calculated for the relationship between 1-RM data and peak torques for the entire population and for subgroups defined by age and gender. One-repetition maximum strength correlated strongly with the dynamometer results. One-repetition maximum leg extension correlated more strongly with peak torques than did 1-RM leg press (0.78

