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Updated: Jun 27, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
[Distribution signature analysis between intussusception and rotavirus diarrhea in young children]
Qing-Bin Wu1, Hong-Ying Gu, Wei-Guo Tang
1Department of Gastroenterology, Children' s Hospital, Suchow University, Suzhou 215003, China. qingbin6638@yahoo.com.cn
Insights
The annual incidence of intussusception in Suzhou children under one year old was 418.1 per 100,000 child-years. This study found no evidence linking intussusception to rotavirus diarrhea in this population.
Area of Science:
- Pediatrics
- Epidemiology
- Infectious Disease
Context:
- Intussusception is a serious intestinal condition in young children.
- Understanding its incidence and potential triggers is crucial for public health.
- Rotavirus is a common cause of diarrhea in infants and young children.
Purpose:
- To determine the annual incidence rate of intussusception in Suzhou over a 5-year period.
- To investigate a potential association between intussusception and rotavirus diarrhea in children under two years old.
Summary:
- A 5-year retrospective review (1999-2003) of 1101 intussusception cases in children under two years old in Suzhou.
- The average annual incidence of intussusception in infants under one year was 418.1 per 100,000 child-years.
- No epidemiological evidence supported a link between intussusception and rotavirus diarrhea, despite distinct age and seasonal patterns for each condition.
Impact:
- Provides crucial epidemiological data on intussusception incidence in a specific region.
- Informs public health strategies and clinical management of pediatric intussusception.
- Highlights the need for further research into the multifactorial causes of intussusception.
Objective:
To investigate the annual incidence rate of intussusception over a 5-year period in Suzhou and to determine whether there was a potential link between intussusception rotavirus diarrhea.
Methods:
Outpatient and inpatient data from 1999 through 2003 retrospectively were reviewed for young children (< 2 year old) whose diagnosis was confirmed by ultrasonography or radiography and patients were reduced by air enema or surgery. From September 2001, to August 2003, inpatients with diarrhea (< 2 year old) were detected rotavirus antigen in the stool by ELISA technology.
Results:
From 1999 through 2003, 1101 cases were reported in children below 2 years old. The incidence rate of intussusception under 1 year age each year was 275.3, 338.2, 547.0, 515.3, and 425.4 per 100,000 child years respectively (the average annual incidence was 418.1 per 100,000 child years), and the incidence of intussusception increased over time from 1999 to 2003. A peak age distribution of intussusception was infants 4 to 10 months old (692/1101, 62.85%) and mean age was 9.62 +/- 5.65 months, which were greatly different from those of patients with rotavirus diarrhea, whose peak age distribution was 5 to 16 months old (252/331, 76.13%), and mean age was 11.42 +/- 5.14 months (Z = 6.90, P < 0.01). The peak month distribution of intussusception was from April to August (595/1101, 54.04%), which was distinct from that of patient with rotavirus diarrhea, whose peak month distribution was between October and January (232/331, 70.09%). Test: chi2 = 226.06, P < 0.001.
Conclusion:
The annual incidence rate of intussusception for < 1 year of age was 418.1 per 100,000 child years in Suzhou. We found no epidemiologic evidence for an association between intussusception and rotavirus diarrhea.
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