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Updated: Jun 27, 2026
Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
Published on: July 3, 2018
[Effect of Candida albicans growth on silicone elastomer containing nano-TiO2]
Bei Li1, Yi-Min Zhao, Ju-Cai Yang
1Department of Prosthodontics, College of Stomatology, The Fourth Military Medical University, Xi'an, China.
Objective:
To study the antibacterial effect against Candida albicans of the A-2186 silicone elastomer containing nano-TiO2 in vitro.
Methods:
Antibacterial agent of nano-TiO2 was added into A-2186 silicone elastomer with incorporating percentages of 0.5%, 1.0%, 1.5%, and 2.0% (W/W). There was no nano-TiO2 in the control group. The antibacterial effect of the A-2186 silicone elastomer was determined using the film contact method with lighting and without lighting.
Results:
Either with lighting or without lighting, there were significances between the experiment groups and the control group (P < 0.05). When the incorporating percent was 2.0%, the inhibitory effect was the best among the experiment groups. Without lighting, the inhibitory rate was 53.7% and with lighting, the inhibitory rate was 85.9%.
Conclusions:
The A-2186 silicone elastomer containing nano-TiO2 has antibacterial properties against Candida albicans, which enhances with increases of nano-TiO2 percent in the material. With the same incorporating percentage, the antibacterial effect with lighting is better than that without lighting.
