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Antiphospholipid antibodies and recurrent abortion
F Parazzini1, B Acaia, D Faden
1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Obstetrics and Gynecology
|June 1, 1991
Summary
Antiphospholipid antibodies, including lupus anticoagulant and anticardiolipin antibodies, are significantly associated with recurrent spontaneous abortion. This study provides quantitative evidence linking these antibodies to an increased risk of pregnancy loss.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Reproductive Medicine
Background:
- Recurrent spontaneous abortion (RSA) affects a significant number of women.
- The role of antiphospholipid antibodies in RSA requires further quantitative investigation.
Purpose of the Study:
- To investigate the association between anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and the risk of recurrent spontaneous abortion.
- To provide quantitative evidence for the link between antiphospholipid antibodies and RSA.
Main Methods:
- A case-control study was conducted in northern Italy.
- Included 220 women with two or more unexplained consecutive spontaneous abortions (cases) and 193 controls.
- Assessed presence and levels of aCL and LA in cases and controls.
Main Results:
- Lupus anticoagulant was detected in 7% of cases versus 0% of controls (P < .001).
- Increased anticardiolipin antibody levels were found in 19% of cases versus 3% of controls.
- Specific antibody isotypes (IgG, IgM) were detailed for cases and controls.
Conclusions:
- The study provides quantitative evidence supporting the association between antiphospholipid antibodies and recurrent spontaneous abortion.
- Lupus anticoagulant and anticardiolipin antibodies are significant risk factors for recurrent pregnancy loss.