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Updated: Jun 27, 2026

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Published on: April 24, 2009

Do rats with retrosplenial cortex lesions lack direction?

Helen H J Pothuizen¹, John P Aggleton, Seralynne D Vann

¹School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK.

The European Journal of Neuroscience

|November 27, 2008

Summary

Bilateral retrosplenial cortex lesions in rats impair spatial navigation strategies, particularly those relying on directional cues for alternation. This highlights the retrosplenial cortex's crucial role beyond allocentric processing.

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Area of Science:

Neuroscience
Cognitive Science
Spatial Navigation

Background:

The retrosplenial cortex integrates various spatial cues, but its role beyond allocentric processing is not fully understood.
Understanding retrosplenial cortex function is key to deciphering complex spatial navigation mechanisms.

Purpose of the Study:

To investigate the impact of retrosplenial cortex lesions on different spatial strategies in rats.
To assess the contribution of the retrosplenial cortex to direction alternation and spatial working memory.

Main Methods:

Rats with bilateral retrosplenial cortex lesions were trained on T-maze alternation tasks under varying conditions (light/dark) to assess direction alternation.
Spatial working memory was evaluated using a radial-arm maze with mid-trial rotations.

Main Results:

Retrosplenial cortex lesions selectively impaired direction alternation, suggesting a deficit in using head-direction information.
Lesions also caused deficits in spatial working memory when the maze was rotated, consistent with previous findings.

Conclusions:

Retrosplenial cortex lesions disrupt the use of directional cues for alternation.
These findings underscore the retrosplenial cortex's critical role in allocentric navigation, path integration, and direction-based spatial strategies.