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Animal models in systemic sclerosis.

V Rogai¹, R J Lories, S Guiducci

¹Department of Biomedicine, Division of Rheumatology, University of Florence, AOUC, Florence, Italy. vrogai@hotmail.com

Clinical and Experimental Rheumatology

|November 27, 2008

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Systemic sclerosis (SSc) research utilizes animal models to understand fibrosis. These models, though imperfect, mimic SSc

Area of Science:

Rheumatology and immunology research.
Pathogenesis of fibrotic diseases.

Background:

Systemic sclerosis (SSc) is a complex autoimmune disease characterized by widespread fibrosis.
The unknown etiology of SSc necessitates the use of animal models for research.
Current animal models partially replicate SSc manifestations, particularly tissue fibrosis.

Purpose of the Study:

To review principal animal models of Systemic Sclerosis (SSc).
To discuss the molecular pathways involved in SSc pathogenesis.
To highlight the utility of animal models in understanding fibrotic diseases.

Main Methods:

Categorization of animal models into genetically mutated and induced models.
Review of literature on established SSc animal models.

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Analysis of molecular pathways implicated in fibrosis.

Main Results:

Animal models are crucial for studying SSc pathogenesis and testing therapies.
Models include genetically modified mice (tight skin 1 and 2) and induced models like sclerodermatous graft-vs-host disease (Scl GVHD).
All models exhibit fibrotic changes similar to human SSc.

Conclusions:

Animal models are indispensable tools for understanding SSc.
Further development of models is crucial for elucidating molecular pathways of fibrosis.
Future models will aid in identifying and testing targeted therapeutic agents for SSc.